Dr. Srivani Veeranarayanan
(Thesis Title: Mesoporous silica nanomaterials and silica coated nanomaterials - application in optical imaging and treatment of cancer related angiogenesis.
Post - Doc Researcher,
Bio Nano Electronics Research Center,
Graduate School of Interdisciplinary New Science,
Toyo University, Kawagoe, Saitama, Japan.
- B.Sc. Plant Biology and Plant Biotechnology, University of Madras, 2005.
- M.Sc. Biomedical Genetics, Institute of Basic Medical Science, University of Madras, 2007.
- Ph.D. Bionanotechnology, Bio - Nano fusion science course, Graduate School of Interdisciplinary New Science, Toyo University, Japan, 2012.
Lecturer, Department of Genetics and Biotechnology, Prof. Dhanapalan College for Women, University of Madras, Chennai (December 2007 - July 2008).
- Awarded Monbukagakusho MEXT Scholarship, Japan - 2009.
- University First Rank Holder in B.Sc.
- University Second Rank Holder in M.Sc.
- Awarded Consecutive Merit Scholarship for excellence in studies from HFL.
Angiogenesis stands as a major hallmark in all types of cancer. Cancer, to grow uncontrollably needs essential nutrients and oxygen in high levels and they turn on synthesis of all known angiogenic factors leading to angiogenesis. Thus formed blood vessels feed the cancerous mass and also help in process of metastasis of cancer to a distant region. Targeting the angiogenesis with silica nanoformulations stands as efficient treatment therapeutics to treat cancer. Cutting their blood supply would make cancerous mass to starve for oxygen, nutrients etc., and would also prevent them from infiltrating to distant regions, thereby preventing secondary tumors.
Scheme of research:
Synthesis of highly porous silica nanoparticle and silica coated nanomaterials for theragnostic application of angiogenesis.
- Testing them for their efficacy in imaging and therapeutics in in vitro cell cultures using HUVEC and breast cancer cell lines.
- Medaka embryos vascular disruption study - Pharmacological inhibition of Angiogenesis in vivo using the anti - angiogenic nanoformulation.
Mesoporous silica nanoparticles are synthesized via modified template directed stober process using tetraethoxy silane as silica source. The mesopores are then efficiently loaded with drug/dye of interest and this nanoformulation is utilized for synergistic targeting of cancer and its related angiogenesis. In vitro and in vivo works are carried out and the efficacy of the nanoformulation against angiogenesis is elucidated.
- Microemulsion methodology was utilized to prepare silica encapsulated single CdS quantum dots of highly uniform size (20nm). The core CdS are highly luminescent and this core - shell particle appeared to be highly biocompatible and is utilized for endothelial imaging by active targeted mechanism.
- Drug loaded core - shell magnetic nanoparticle with silica coating are prepared using microemulsion method and these nanoparticles are intended to be used for magnetic separation and hyperthermic therapeutic treatment of cancer
- FITC labeled Silica Nanoparticles as Efficient Cell Tags: Uptake and Photostability Study in Endothelial cells. V. Srivani, C.P. Aby, Sheikh M, A. Aravind, Y. Nagaoka, Y. Yoshida, T. Maekawa, D. Sakthi Kumar. Journal of Fluorescence, 2012, Volume 22, Number 2, Pages 537 - 548 (DOI: 10.1007/s10895 - 011 - 0991 - 3).
- Aptamer functionalized silica nanoparticles for targeted cancer therapy. Athulya A, V. Srivani, Aby C. P, Remya Nair, Y. Nagaoka, Y. Yoshida, T. Maekawa, D. Sakthi Kumar. BioNanoScience, 2012, Volume 2, Number 1, Pages 1 - 8 (DOI: 10.1007/s12668 - 011 - 0029 - y).
- Synthesis of aqueous CdS and silica coated CdS quantum dots and their application in optical cell imaging. V. Srivani, Aby C. P, S. Mohamed, Y. Nagaoka, Seiki I, Y. Nakagame, S. Kashiwada, Y.Yoshida, T.Maekawa, D. Sakthi Kumar. International Journal of Nanomedicine, 2012 (In Press).
- Synergistic Targeting of Cancer and Associated Angiogenesis Exercising Triple Targeted - Dual Drug Silica Nanoformulations for Theragnostics. V. Srivani, Aby C. P, S. Mohamed, S. H. Varghese, Y. Nagaoka, Y.Yoshida, T.Maekawa, D. Sakthi Kumar. Small, 2012 (Accepted).
- PEG Coated Biocompatible Cadmium Chalcogenide Quantum Dots for Targeted Imaging of Cancer Cells. C.P. Aby, V. Srivani, Sheikh M, Sreejith R, Y. Nagaoka, Y. Yoshida, T. Maekawa, D. Sakthi Kumar. Journal of Fluorescence, 2012 (DOI: 10.1007/s10895 - 011 - 1032 - y).
- Rapid synthesis of triangular CdS nanocrystals without any trap emission. C.P. Aby, V. Srivani, Y. Yoshida, T. Maekawa, D. Sakthi Kumar. Journal of Nanoparticle Research, 2012, Volume 14, Number 4, 789 (DOI: 10.1007/s11051 - 012 - 0789 - 5).
- Synthesis of CuAlS2 nanocrystals and its application in bioimaging. C.P. Aby, V. Srivani, A. Aravind, Y. Nagaoka, Y. Yoshida, T. Maekawa, D. Sakthi Kumar. Materials Express, 2 (2012) 94 .
- Functionalized Electrophoretic deposition of CdSe QDs on to TiO2 electrode for photovoltaic application. C.P. Aby, V. Srivani, Y. Yoshida, T. Maekawa, D. Sakthi Kumar. Chemical Physics Letter, 2012 ( In press).
- Aptamer - labeled PLGA nanoparticles for cancer therapy. Athulya A. Saino H. Varghese, V. Srivani, Anila M., Y. Nagaoka, T. Fukuda, T. Hasamura, T. Iwai, Y. Yoshida, T. Maekawa, D. Sakthi Kumar. Cancer Nanotechnology, 2012 (DOI: 10.1007/s12645 - 011 - 0024 - 6).
- Aptamer - PLGA - Lecithin - PEG nanoparticles prepared by nanoprecipitation & self - assembly: prospective application in drug loading, controlled drug release and targeted drug delivery. Athulya A. V. Srivani, Prashanthi J, Y. Nagaoka, T. Fukuda, T. Hasamura, T. Iwai, Y. Yoshida, T. Maekawa, D. Sakthi Kumar. Biotechnology and Bioengineering, 2012 (In press).
- Cytocidal and ROS activity of curcin augmented organelle and membrane protein disruption - A possible curb for metastasis of breast and brain cancers. M. Sheikh Mohamed, V. Srivani, Hiroaki Minegishi, Yasuhiro Shimane, Yutaka Nagaoka, Akinobu Echigo, Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar. (To be submitted - Cellular and Molecular Life Sciences, 2012).
Seminars and Paper Presentation
Nanoformulation mediated disruption of vasculogenesis in medaka fish model - approach towards patho - angiogenic treatment - Poster. 9th International Symposium on Bioscience and Nanotechnology, Toyo University, Japan. December 10, 2011. Oral - Itakura Life Science Committee presentation.
- Drug loading in porous Silica Nanoparticle and invitro study of cytotoxicity - Poster. 8th International Symposium on Bioscience and Nanotechnology, Toyo University, Tokyo, Japan. 17 - 18 December, 2010.
- Synthesis of greener Quantum dots and invitro study of nano - cytotoxicity. - Poster. Nanosafe - 2010, Grenoble, France. 16 - 18 November 2010.
- Nanoparticle mediated Angiogenesis inhibitor delivery to suppress tumor vasculature in Breast cancer. - Poster. 7th International Symposium on Bioscience and Nanotechnology, Tokyo, Japan. 20 - 21 November 2009.
- Breast cancer angiogenesis as therapeutic target. Departmental presentation, Toyo University, Saitama, Japan. 2nd July, 2009.