Bionano Electronics Research Centre,
Graduate School of Interdisciplinary New Science,
Toyo University,
2100, Kujirai, Kawagoe, Saitama 350-8585,
Japan

Educational Qualifications

• BSc. Biotechnology (2001-2004) from Maharaja College for Women, Erode (Bharathiar University, Coimbatore, Tamil Nadu, India).
• Advanced Diploma in Bioinformatics (2005-2006) from DR.G.R.Damodaran College of Science (Autonomous) (Bharathiar University, Coimbatore, Tamil Nadu, India).
• MSc. Biotechnology (2004-2006) from DR.G.R.Damodaran College of Science (Autonomous) (Bharathiar University, Coimbatore, Tamil Nadu, India).
• Ph.D (April 2009- ).

Professional History

1. Guest lecturer in Dept. Of Biotechnology, JDT Arts and Science College, Calicut (July 2006-November 2006)
2. Research Assistant in Human Molecular Genetics Laboratory, Rajiv Gandhi Centre for Biotechnology (January 2007-March 2009)

Awards, Fellowships and Honors

1. Recipient of Japanese Government Monbukagusho - MEXT Scholarship (2009).
2. Qualified the NET (National Eligibility Test –Lectureship) 2007.
3. Qualified GATE (Graduate Aptitude Test in Engineering) 2007.

Synthesis and characterisation of targeted nano-regulators into brain for controlling Alzheimer's Disease.

Alzheimer’s disease (AD) is a serious debilitating disorder which is highly prevalent all over the world and is characterized by a progressive, age-related cognitive decline that ultimately results in memory loss, loss of language skills, difficulty performing routine tasks, disorientation and personality changes. The two pathological hallmarks of AD are the accumulation of intracellular neurofibrillary tangles and extracellular amyloid plaques. The major constituent of the amyloid plaque is Aß peptide or ß-amyloid and aggregation of this peptide is a major causative factor in AD. The Aß-peptide arises via cleavage of the amyloid precursor protein (APP), single transmembrane protein. Cholesterol is proving to be an important factor in the development of AD as, elevated cellular cholesterol content has been shown to favor production of the amyloid-ß (Aß) peptide. As a master regulator of cholesterol homeostasis, Liver X Receptors can be considered a potential molecular target for the treatment of AD. LXR ligand-aptamers can be synthesised for the control of Cholesterol homeostasis in brain. This can be targeted into the brain using an Alzheimer neuron targeting aptamer. These can be conjugated on a gold/silver nanorod and biopolymer coated for delivery into the brain.

Publications

• Alzheimer’s disease: A curse of Cholesterol? (Review article- to be submitted). A.Mathew, T. Maekawa, Y. Yoshida, D. Sakthi Kumar .
• Universal Protocol for Generating 100bp Size Standard for Endless Usage. C. Natarajan, N.V. Neetha, K.V. Linda, A. Mathew, L. Srinivas and M. Banerjee. Electronic Journal of Biotechnology (online) 15 April 2008, vol. 11, no. 2. http://www.ejbiotechnology.cl/content/vol11/issue2/full/10/index.html.

Seminars and Presentations

• A. Mathew, T. Maekawa, Y. Yoshida, D.Sakthi Kumar (2009) “Synthesis and Characterisation of Targeted Nano-Regulators into Brain for Controlling Alzheimer's Disease” 7th International Symposium on Bioscience and Nanotechnology, Tokyo, Japan.
• A. Das, A. Mathew, N. Vijayan, K. Radakrishnan, M. Banerjee (2009) “A Novel Association of ATP-Binding Casette Family Gene (ABCB1) Among South Indian Patients With Epilepsy” American Academy of Neurology Conference, Seattle, USA (Best Poster Award), Poster No IN2-1.008.
• A. Mathew, M. Jose, N.V. Neetha, K.V. Linda, S.V. Thomas and M. Banerjee (2008) “Investigating the Role of Polymorphisms in MDR1 and MTHFR with Teratogenicity of Antiepileptic Drugs.” Human Genome Organization’s 13th Human Genome Meeting held at Hyderabad. Page 187, Poster 366.
• S.A. Vahab, S.S. Gupta, A. Mathew, N. Ravindran, N.V. Neetha, S. Mony, G. Nayak, N. Bhaskaranand, M. Banerjee and K. Sathyamoorthy (2008) “Evaluating the Effect of Genotype and Haplotype Frequencies of ABCB1 (MDR1) Polymorphisms in Medically Refractory Epilepsy Patients of an Indian Population.” Human Genome Organization’s 13th Human Genome Meeting held at Hyderabad. Page 182, Poster 349.
• N.V. Neetha, K.V. Linda, N. Chandrasekhar, A. Mathew, C. Nair, P. Allencherry and M. Banerjee (2008) “Association Studies of Neurotransmitter Receptor and Transporter Genes in the Theranostics of Schizophrenia in a South Indian Population.” Human Genome Organization’s 13th Human Genome Meeting held at Hyderabad. Page 224, Poster 496.
• A. Mathew, A. Das, P.P. Ram, N.V. Neetha, K.V. Linda, N. Chandrasekhar, K. Radhakrishnan and M. Banerjee (2007) “Impact of MDR1 Haplotype Bearing C3435T Polymorphism in Medically Refractory Mesial Temporal Lobe Epilepsy Patients from Kerala” International Symposium on Dissecting the Role of Genes and Environment in Complex Diseases held at Centre for Cellular and Molecular Biology, Hyderabad, Page P-1, Poster 1.