Nanodrug delivery
Nanotechnology is emerging as a new field enabling the creation and application of materials, devices and systems at atomic and molecular levels and the exploitation of novel properties that emerge at the nanometer scale. Many areas of biomedicine are expected to benefit from nanotechnology including sensors for use in laboratory, the clinic and even within the human body; new formulations and routes for drug delivery; and biocompatible; high ? performance materials for use in implants.
Even though we have advanced in modern technologies such a way that, now we are at cross roads to take a decision, whether is it wise to start human cloning from cells or not?; we were forced to bow in front of the malignant disease caused to cells, known as ? CANCER. Even in these days also many human beings are surrendering their life in front of this disease, since there were no path breaking discoveries surfaced to counter cancer in the past two decades. Cancer can cause any where in the parts of human body from skin to brain. Many treatments were proposed to tackle this problem but all of them were not sufficient and safe from side effects. We do feel that to counter this disease, the only way in front of us is to make drugs in nanometer size which will be covered by biocompatible biodegradable polymers and cancer cell detecting sensors (aptamer sensors ? DNA/RNA based sensors), to detect the cancer affected micro sized cells and deliver the lethal doze, only to cancer affected cells leaving living cells unaffected. We would like to call this system as ?NANO BOMBS?. We are anticipating to make a system which is very similar to modern missile technologies, such a way that the missile can deliver the lethal payloads at selected sites, where it need to make severe damages. Even though this approach is suitable to any where in the part of our body, it will be most suited for brain tumors. The position of some tumors inside the brain makes us difficult to get operated or do chemotherapy since it will cause damage to a large number of living cells. The location of the brain tumor often determines if surgery can safely remove all the brain tumor cells or not. If a brain tumor is deep in the brain, surgery may not be able to safely remove the tumor in all cases. In this juncture we can expect some help from the newly emerged branch of technology named as nanotechnology. After developing core drug in nanoparticles, we will coat them with bio compatible polymers and attach cancer cell detecting sensors that are able to target the nano bombs to the desired location. We would like to use the only effective method known as plasma fluidization, which can coat polymers on nanoparticles even up to the size of 10 nm., since no other method has been proposed till date for coating polymers on nanoparticles of the size effectively. This will in turn increase the drug payload compared to any other method.
- Biomaterials by plasma processing and its applications in Bio-Nano technology. (Invited Talk)
D. Sakthi Kumar, Yasuhiko Yoshida
Recent advances and new directions in Bio-Nanotechnology
Institute for Collaborative Biotechnologies, University of California, USA, August
6-8, 2007.
- Importance of plasma polymer biomaterials in Nanodrug delivery and other futuristic applications.
D.Sakthi Kumar, Yasuhiko Yoshida
Proceedings of the International symposium on novel techniques in nano biology (2005) 123 - 129.
- Bio polymer developed from Geraniol - An effective material to modify the surface of nano drugs
(Poster)
D.Sakthi Kumar,T.Minemoto,RYoshinaka,K.Asano,A.Jayakrishnan,Yasuhiko Yoshida
Fourth Asian International symposium on Biomaterials & Second International Symposium on fusion of Nano and Bio Technologies Tsukuba, Japan November 16 -18, 2004.
- Bio compatible polymer developed from citral - Initial step for a gateway to check and eradicate tumor cells (Poster)
D.Sakthi Kumar,R.Yoshinaka,T.Minemoto,K.Asano,A.Jayakrishnan,YasuhikoYoshida
5 th International Seminar on Bio Physics Gotemberg, Sweden August 23 - 27, 2004
